Department of Oral Implantology, Faculty of Dentistry, Istanbul University, 34093 Istanbul, Turkey.
Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY 10010, USA.
Bioinorg Chem Appl. 2014;2014:829496. doi: 10.1155/2014/829496. Epub 2014 Aug 18.
It is important to develop functional transmucosal implant surfaces that reduce the number of initially adhering bacteria and they need to be modified to improve the anti-bacterial performance. Commercially pure Ti sheets were anodized in an electrolyte containing ethylene glycol, distilled water and ammonium fluoride at room temperature to produce TiO2 nanotubes. These structures were then annealed at 450°C to transform them to anatase. As-annealed TiO2 nanotubes were then treated in an electrolyte containing 80.7 g/L NiSO4 ·7H2O, 41 g/L MgSO4 ·7H2O, 45 g/L H3BO3, and 1.44 g/L Ag2SO4 at 20°C by the application of 9 V AC voltage for doping them with silver. As-annealed TiO2 nanotubes and as-annealed Ag doped TiO2 nanotubes were evaluated by SEM, FESEM, and XRD. Antibacterial activity was assessed by determining the adherence of A. actinomycetemcomitans, T. forsythia, and C. rectus to the surface of the nanotubes. Bacterial morphology was examined using an SEM. As-annealed Ag doped TiO2 nanotubes revealed intense peak of Ag. Bacterial death against the as-annealed Ag doped TiO2 nanotubes were detected against A. actinomycetemcomitans, T. forsythia, and C. rectus indicating antibacterial efficacy.
开发具有减少初始附着细菌数量的功能黏膜植入物表面非常重要，需要对其进行修饰以提高抗菌性能。商业纯钛片在含有乙二醇、蒸馏水和氟化铵的电解质中于室温下进行阳极氧化，以生成 TiO2 纳米管。然后将这些结构在 450°C 下退火，将其转化为锐钛矿相。然后，将退火后的 TiO2 纳米管在含有 80.7g/L NiSO4·7H2O、41g/L MgSO4·7H2O、45g/L H3BO3 和 1.44g/L Ag2SO4 的电解质中，在 20°C 下通过施加 9V AC 电压进行处理，以掺杂银。通过 SEM、FESEM 和 XRD 对退火后的 TiO2 纳米管和退火后的 Ag 掺杂 TiO2 纳米管进行了评估。通过确定 A. actinomycetemcomitans、T. forsythia 和 C. rectus 对纳米管表面的粘附来评估抗菌活性。使用 SEM 检查细菌形态。退火后的 Ag 掺杂 TiO2 纳米管显示出强烈的 Ag 峰。对退火后的 Ag 掺杂 TiO2 纳米管检测到针对 A. actinomycetemcomitans、T. forsythia 和 C. rectus 的细菌死亡，表明具有抗菌功效。
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