Medical Genetics Unit, Department of Surgical and Biomedical Sciences, University of Perugia Perugia, Italy.
Front Genet. 2014 Aug 25;5:294. doi: 10.3389/fgene.2014.00294. eCollection 2014.
Various explanations have been advanced for the evolution of genomic imprinting, the most popular of these being the parental conflict hypothesis. However, while this theory may explain why there has been selection for imprinting certain genes, it does not explain how the maternal and paternal genomes can be distinguished from each other. Here, we hypothesize that the temperature at which male and female gonads are physiologically exposed could be, at least for some loci, the primary factor leading to the different imprinting between the sexes.
已经提出了多种解释来阐明基因组印迹的进化,其中最流行的是亲本冲突假说。然而,尽管该理论可以解释为什么选择印迹某些基因,但它并不能解释为什么可以区分母本和父本基因组。在这里,我们假设雄性和雌性生殖腺在生理上暴露的温度至少在某些基因座上可能是导致性别间印迹不同的主要因素。