Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide 5000, Australia.
Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide 5000, Australia; School of Medicine, University of Adelaide, Adelaide 5000, Australia.
Dev Cell. 2014 Sep 8;30(5):490-1. doi: 10.1016/j.devcel.2014.08.021.
Decoy receptors have ligand binding capacity but, in contrast to cognate receptors, do not initiate typical downstream signaling cascades. In this issue of Developmental Cell, Klein and colleagues (2014) demonstrate that CXCR7 acts as a decoy receptor for adrenomedullin, a peptide hormone with key roles in cardiovascular development.
诱饵受体具有配体结合能力，但与同源受体不同，它们不会引发典型的下游信号级联反应。在本期《发育细胞》中，Klein 及其同事（2014）证明，CXCR7 作为肾上腺髓质素的诱饵受体发挥作用，肾上腺髓质素是一种在心血管发育中起关键作用的肽类激素。
