吸入速尿对预防超声雾化水诱发的支气管收缩非常有效。

Inhaled frusemide is highly effective in preventing ultrasonically nebulised water bronchoconstriction.

作者信息

Robuschi M, Gambaro G, Spagnotto S, Vaghi A, Bianco S

机构信息

Institute of Lung Diseases, University of Milan, Italy.

出版信息

Pulm Pharmacol. 1989;1(4):187-91. doi: 10.1016/s0952-0600(89)80016-x.

DOI:10.1016/s0952-0600(89)80016-x

PMID:2520344

Abstract

A decrease in the osmolarity of the periciliary fluid of central airways is supposed to be the initiating mechanism by which ultrasonically nebulised distilled water (UNH2O) induces bronchoconstriction in asthmatics. It is therefore possible that substances, such as frusemide (F), which, in vitro, interfere with ions and water translocation across the tracheo-bronchial epithelium, can also modify such response. To test this hypothesis, 16 adult asthmatics were challenged with UNH2O after being pretreated with either inhaled F (approximately 28 mg delivered into the mouth) or placebo (the diluent) administered in random order and double-blind by means of a jet nebuliser. F did not modify baseline FEV1 and sRaw but attenuated markedly their changes after UNH2O. Mean max % (95% CI) sRaw increases after placebo and F were 293% (168-419) and 63% (21-104), respectively; mean max % falls in FEV1 were 26% (20-32) and 6% (-1-12). Thus inhaled F is highly effective in preventing UNH2O-induced bronchoconstriction and this unexpected property could have therapeutic implications.

摘要

中央气道纤毛周围液体渗透压的降低被认为是超声雾化蒸馏水（UNH₂O）诱发哮喘患者支气管收缩的起始机制。因此，像呋塞米（F）这样在体外会干扰离子和水跨气管支气管上皮转运的物质，也可能改变这种反应。为了验证这一假设，16名成年哮喘患者在随机顺序、双盲条件下，通过喷射雾化器分别预先吸入F（约28mg喷入口腔）或安慰剂（稀释剂），之后用UNH₂O进行激发试验。F并未改变基础第一秒用力呼气容积（FEV₁）和比气道阻力（sRaw），但显著减弱了它们在接触UNH₂O后的变化。安慰剂组和F组sRaw的平均最大增加百分比（95%可信区间）分别为293%（168 - 419）和63%（21 - 104）；FEV₁的平均最大下降百分比分别为26%（20 - 32）和6%（-1 - 12）。因此，吸入F能非常有效地预防UNH₂O诱发的支气管收缩，这一意外特性可能具有治疗意义。