Imai Y, Yamakawa M, Matsuda M, Kasajima T
Department of Pathology, Yamagata University, School of Medicine, Japan.
Histol Histopathol. 1989 Jan;4(1):39-45.
The reactions of four anti-sex hormone (Estrone, Estradiol, Estriol and Testosterone) antisera were immunohistochemically examined in 109 cancerous and 80 normal and benign thyroid tissues. Four kinds of sex hormones were detected in the tumour cells of 61 cases (56%) of thyroid cancer and in the follicular epithelial cells of 4 cases (5%) of normal and benign thyroid tissues. Among the thyroid cancers, 54 female (61%) and 7 cases in males (33%) were positive for sex hormones. Furthermore, estrogen binding activity was screened histochemically in 36 thyroid tissues of various types, and detected not only in thyroid cancer (6/15 cases), but in normal and benign thyroid tissues (4/21 cases) as well. It was concluded that endogenous estradiol was located in thyroid cancers more frequently in females than in males and that there was estrogen binding activity in the cells of not only thyroid cancers, but also normal and benign thyroid tissues. This is the first report of the demonstration of endogenous sex hormones in thyroid cancer.
对109例癌性甲状腺组织以及80例正常和良性甲状腺组织进行免疫组化检查，观察4种抗性激素（雌酮、雌二醇、雌三醇和睾酮）抗血清的反应。在61例（56%）甲状腺癌的肿瘤细胞以及4例（5%）正常和良性甲状腺组织的滤泡上皮细胞中检测到4种性激素。在甲状腺癌中，54例女性（61%）和7例男性（33%）的性激素呈阳性。此外，对36例不同类型的甲状腺组织进行组织化学筛选雌激素结合活性，结果不仅在甲状腺癌（6/15例）中检测到，在正常和良性甲状腺组织（4/21例）中也检测到。研究得出结论，内源性雌二醇在女性甲状腺癌中的定位比男性更频繁，并且不仅在甲状腺癌细胞中，而且在正常和良性甲状腺组织细胞中均存在雌激素结合活性。这是关于甲状腺癌中内源性性激素的首次报道。
