Roberts J A, Thomson N C
Department of Respiratory Medicine, Western Infirmary, Glasgow, UK.
Pulm Pharmacol. 1989;2(2):103-5. doi: 10.1016/0952-0600(89)90031-8.
Allergen exposure may precipitate acute bronchoconstriction and increase bronchial reactivity. We have investigated whether passive sensitisation of human airway per se or short-term exposure to mediators released by specific antigen exposure produces an alteration in in vitro smooth muscle sensitivity to histamine. Exposure to allergen produced smooth muscle contraction in sensitised tissue, but subsequent smooth muscle sensitivity to histamine was not altered. We conclude that neither passive sensitisation nor short-term exposure to mast cell mediators alters in vitro smooth muscle sensitivity to histamine.
接触过敏原可能会引发急性支气管收缩并增加支气管反应性。我们研究了人体气道的被动致敏本身或短期接触由特异性抗原暴露释放的介质是否会改变体外平滑肌对组胺的敏感性。接触过敏原会使致敏组织中的平滑肌收缩，但随后平滑肌对组胺的敏感性并未改变。我们得出结论，被动致敏和短期接触肥大细胞介质均不会改变体外平滑肌对组胺的敏感性。
