利维-52对雌性白化大鼠铍毒性的保护作用。

Liv-52 protection against beryllium toxicity in female albino rats.

作者信息

Mathur R, Mathur S, Prakash A O

机构信息

School of Studies in Zoology, Jiwaji University, Gwalior, India.

出版信息

Reprod Toxicol. 1989;3(4):249-60. doi: 10.1016/0890-6238(89)90019-1.

DOI:10.1016/0890-6238(89)90019-1

PMID:2520528

Abstract

Toxic effects of beryllium salts on the reproductive organs of cyclic adult female albino rats have been studied. An attempt was made to overcome these effects using an Ayurvedic medicine Liv-52 (Himalaya Drug Co., Bombay). Liv-52-primed rats (1 mL/rat/day for 15 days) were exposed to beryllium nitrate intravenously and were sacrificed at different time intervals. At autopsy ovary, uterus, cervix, and vagina were processed for biochemical and histopathologic examination. Histoarchitecture of the ovary, uterus, cervix, and vagina revealed severe necrotic changes with beryllium nitrate treatment. Tissue glycogen content and the activity of alkaline phosphatase were inhibited significantly after beryllium treatment. Total and esterified cholesterol levels increased significantly in these organs when exposed to beryllium salts. However, a significant improvement was observed in the biochemical parameters and histoarchitecture of these organs when beryllium was injected into Liv-52-primed animals.

摘要

已对铍盐对成年雌性白化循环大鼠生殖器官的毒性作用进行了研究。尝试使用阿育吠陀药物Liv-52（喜马拉雅制药公司，孟买）来克服这些影响。用Liv-52预处理的大鼠（1毫升/只/天，共15天）经静脉注射硝酸铍，并在不同时间间隔处死。尸检时，对卵巢、子宫、宫颈和阴道进行生化和组织病理学检查。硝酸铍处理后，卵巢、子宫、宫颈和阴道的组织架构显示出严重的坏死变化。铍处理后，组织糖原含量和碱性磷酸酶活性受到显著抑制。当暴露于铍盐时，这些器官中的总胆固醇和酯化胆固醇水平显著升高。然而，当将铍注射到用Liv-52预处理的动物体内时，观察到这些器官的生化参数和组织架构有显著改善。