运用寡克隆带技术对多发性硬化症患者的神经生理学和磁共振成像结果进行比较。
Comparison of neurophysiological and MRI findings of patients with multiple sclerosis using oligoclonal band technique.
作者信息
Ellidag Hamit Y, Eren Esin, Erdogan Nezahat, Ture Sabiha, Yilmaz Necat
机构信息
Central laboratories of Antalya Education and Research Hospital of Ministry of Health, Antalya;
Antalya Public Health Center of Ministry of Health, Antalya;
出版信息
Ann Neurosci. 2013 Oct;20(4):149-54. doi: 10.5214/ans.0972.7531.200406.
BACKGROUND
The correlation of oligoclonal bands (OCBs) and intrathecal IgG synthesis are not yet clear in multiple sclerosis (MS).
PURPOSE
In this study, we investigated the OCB situation and IgG index, cranial and cervical magnetic resonance imaging (MRI) findings and also compared visual evoked potentials (VEP) and somatosensorial evoked potentials (SEP) in order to better understand the OCB pattern and pathogenesis.
METHODS
Retrospective study included 40 patients (19 male, 21 female, mean age 29 ± 4,24) with precise MS diagnosis according to McDonald criteria.
RESULT
Sixteen of the patients were OCB negative, and 24 patients were positive. The different between the OCB situation and number of plaques in cranial and cervical MRI, atrophy, oedema and contrast material retention were insignificant. The different between the OCB situation and VEP and SEP were insignificant.
CONCLUSION
These laboratory findings are all specific, all developing via independent mechanisms and are not related to each other during the silence periods of patients.
背景
在多发性硬化症（MS）中，寡克隆带（OCBs）与鞘内IgG合成之间的相关性尚不清楚。
目的
在本研究中，我们调查了OCB情况和IgG指数、头颅和颈椎磁共振成像（MRI）结果，并比较了视觉诱发电位（VEP）和体感诱发电位（SEP），以便更好地了解OCB模式和发病机制。
方法
回顾性研究纳入了40例根据麦克唐纳标准确诊为MS的患者（19例男性，21例女性，平均年龄29±4.24岁）。
结果
16例患者OCB阴性，24例患者阳性。OCB情况与头颅和颈椎MRI斑块数量、萎缩、水肿及造影剂潴留之间的差异无统计学意义。OCB情况与VEP和SEP之间的差异无统计学意义。
结论
这些实验室检查结果均具有特异性，均通过独立机制发展，在患者的静止期彼此无关。
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