Department of Encephalopathy, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, Shaanxi Province, China ; Encephalopathology Key Subject of Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine of the People's Republic of China, Xianyang 712000, Shaanxi Province, China.
Research Room of Traditional Chinese Medicine Internal Medicine, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China.
Neural Regen Res. 2013 Jul 5;8(19):1765-72. doi: 10.3969/j.issn.1673-5374.2013.19.004.
The Xingnao Jieyu capsule has been shown to effectively relieve neurologic impairments and lessen depression. It remains poorly understood whether this capsule can be used to treat post-stroke depression. Thus, in the present study, we established a rat model of post-stroke depression using left middle cerebral artery occlusions in combination of chronic unpredictable stress and solitary housing during development. Experimental rats received intragastric perfusion with 0.82, 0.41, and 0.20 g/kg Xingnao Jieyu capsules separately dissolved in 2 mL distilled water. Fluoxetine served as a positive control. The treatment was conducted over 28 days. Sugar water consumption test, open-field test, real-time fluorescent quantitative PCR and immunohistochemical staining results demonstrated that intragastric perfusion with various doses of Xingnao Jieyu capsules increased sugar water consumption, voluntary behaviors and synaptotagmin mRNA and protein expression in rats with post-stroke depression. These therapeutic effects were similar to those of fluoxetine. These results indicate that Xingnao Jieyu capsules upregulate synaptotagmin expression in hippocampi of rats with post-stroke depression, and exert antidepressant effects.
醒脑解郁胶囊已被证明能有效缓解神经损伤和抑郁症状。但目前尚不清楚该胶囊是否可用于治疗中风后抑郁症。因此，在本研究中，我们采用左大脑中动脉闭塞联合慢性不可预知性应激和独居发育建立了中风后抑郁大鼠模型。实验大鼠分别灌胃给予 0.82、0.41 和 0.20 g/kg 醒脑解郁胶囊，溶于 2 mL 蒸馏水。氟西汀作为阳性对照。治疗持续 28 天。糖水消耗试验、旷场试验、实时荧光定量 PCR 和免疫组织化学染色结果表明，灌胃给予不同剂量的醒脑解郁胶囊可增加糖水消耗、自发性行为以及中风后抑郁大鼠海马突触结合蛋白 mRNA 和蛋白的表达。这些治疗效果与氟西汀相似。这些结果表明，醒脑解郁胶囊可上调中风后抑郁大鼠海马突触结合蛋白的表达，发挥抗抑郁作用。
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