Shaanxi University of Chinese Medicine, Xianyang 712000, Shaanxi Province, China.
Neural Regen Res. 2012 Jan 25;7(3):187-90. doi: 10.3969/j.issn.1673-5374.2012.03.005.
The present study established a rat model of post-stroke depression using incomplete ischemia induced by unilateral carotid artery ligation in combination with solitary raising and subcutaneous injection of a small dose of reserpine. After intragastric perfusion with 45 mg/100 g, 15 mg/100 g, and 7.5 mg/100 g of Xingnao Jieyu for 7, 14 and 21 days, neuronal morphology in the frontal lobe and hippocampus was improved, depression state and voluntary behaviors were also effectively improved in rats with post-stroke depression. Moreover, the effects of Xingnao Jieyu at a dose of 45 and 15 mg/100 g were similar to the traditional antidepressant Prozac.
本研究采用单侧颈总动脉结扎结合孤养和皮下小剂量利血平注射建立大鼠脑卒中后抑郁模型。灌胃给予星瑙降脂片 45mg/100g、15mg/100g、7.5mg/100g 后，7、14、21 天，可改善额叶和海马神经元形态，有效改善脑卒中后抑郁大鼠的抑郁状态和自主行为，且高、中剂量作用与传统抗抑郁药氟西汀相当。
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