Hoişie S, Pencea I, Dimache G, Lupuşoru E C, Grigoraş E, Oiţă V, Buzdzgan R, Anton D A, Ionescu O N, Uliciuc S
Arch Roum Pathol Exp Microbiol. 1989 Oct-Dec;48(4):347-55.
"Orostim" is a polymicrobial immunomodulator for oral administration, obtained from bacterial suspensions, disintegrated by ultrasonics and dried by atomization. The preparation was chemically characterized before and after atomization without presenting essential modifications. Orostim was not shown to be toxic in mice and rats by esophageal intubation, as long as 20 days. The animals presented normal evolution; hemoleukograms, serum proteins and alkaline phosphatase, in rats, did not present significant modifications in comparison with controls. Histopathologic examination of the organs, obtained from mice, treated for 20 days (liver, spleen, lung) did not emphasize modifications in comparison with controls. Circulating neutrophils phagocytosis in rabbits, orally treated with Orostim, was increased as compared to 0 time; serum complement values decreased compared to the initial ones for 0 time but turned to normal and reached even superior limits, 10 days after the treatment ending.
“Orostim”是一种口服的多微生物免疫调节剂，由细菌悬液经超声破碎和雾化干燥制得。该制剂在雾化前后进行了化学表征，未出现本质性改变。通过食管插管给小鼠和大鼠使用Orostim，长达20天，均未显示出毒性。动物表现正常；大鼠的血常规、血清蛋白和碱性磷酸酶与对照组相比未出现显著变化。对经20天治疗的小鼠（肝脏、脾脏、肺）的器官进行组织病理学检查，与对照组相比未发现明显改变。与0时刻相比，口服Orostim治疗的家兔循环中性粒细胞吞噬作用增强；血清补体值与0时刻初始值相比降低，但在治疗结束10天后恢复正常，甚至达到更高水平。
