Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, China ; Taishan Medical University, Taian 271000, Shandong Province, China.
Taian Hospital of Traditional Chinese Medicine, Taian 271000, Shandong Province, China.
Neural Regen Res. 2013 Mar 25;8(9):843-52. doi: 10.3969/j.issn.1673-5374.2013.09.009.
The extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway plays an important role in the mechanism of action of antidepressant drugs and has dominated recent studies on the pathogenesis of depression. In the present review we summarize the known roles of extracellular signal-regulated kinase, cAMP response element-binding protein and brain-derived neurotrophic factor in the pathogenesis of depression and in the mechanism of action of antidepressant medicines. The extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor pathway has potential to be used as a biological index to help diagnose depression, and as such it is considered as an important new target in the treatment of depression.
细胞外信号调节激酶/环磷酸腺苷反应元件结合蛋白/脑源性神经营养因子信号转导通路在抗抑郁药的作用机制中起着重要作用，并且主导了最近关于抑郁症发病机制的研究。在本综述中，我们总结了细胞外信号调节激酶、环磷酸腺苷反应元件结合蛋白和脑源性神经营养因子在抑郁症发病机制和抗抑郁药作用机制中的已知作用。细胞外信号调节激酶/环磷酸腺苷反应元件结合蛋白/脑源性神经营养因子通路有可能被用作帮助诊断抑郁症的生物学指标，因此被认为是治疗抑郁症的一个重要新靶点。
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