Faculty of Pharmacy, Hubei University of Chinese Medicine, Wuhan, 430065, China.
Key Laboratory of Traditional Chinese Medicine Resources and Chemistry of Hubei Province, Wuhan, 430061, China.
Curr Med Sci. 2020 Feb;40(1):123-129. doi: 10.1007/s11596-020-2155-7. Epub 2020 Mar 13.
Albiziae Flos (AF) has been experimentally proven to have an antidepressant effect. However, due to the complexity of botanical ingredients, the exact pharmacological mechanism of action of AF in depression has not been completely deciphered. This study used the network pharmacology method to construct a component-target-pathway network to explore the active components and potential mechanisms of action of AF. The methods included collection and screening of chemical components, prediction of depression-associated targets of the active components, gene enrichment, and network construction and analysis. Quercetin and 4 other active components were found to exert antidepressant effects mainly via monoaminergic neurotransmitters and cAMP signaling and neuroactive ligand-receptor interaction pathways. DRD2, HTR1A, and SLC6A4 were identified as important targets of the studied bioactive components of AF. This network pharmacology analysis provides guidance for further study of the antidepressant mechanism of AF.
槐米（AF）已被实验证明具有抗抑郁作用。然而，由于植物成分的复杂性，AF 在抑郁症中的确切药理作用机制尚未完全破译。本研究采用网络药理学方法构建成分-靶标-通路网络，以探讨 AF 的活性成分及潜在作用机制。方法包括化学成分的收集和筛选、活性成分与抑郁症相关靶点的预测、基因富集以及网络构建和分析。发现槲皮素和其他 4 种活性成分主要通过单胺能神经递质和 cAMP 信号通路以及神经活性配体-受体相互作用通路发挥抗抑郁作用。DRD2、HTR1A 和 SLC6A4 被确定为 AF 中研究生物活性成分的重要靶点。该网络药理学分析为进一步研究 AF 的抗抑郁机制提供了指导。
