Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health, Beijing, China ; Department of Neurology, Jiangbin Hospital, Nanning, Guangxi Zhuang Autonomous Region, China.
Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health, Beijing, China.
Neural Regen Res. 2014 Mar 15;9(6):653-60. doi: 10.4103/1673-5374.130117.
Current evidence shows that apolipoprotein E (APOE), apolipoprotein CI (APOC1) and low density lipoprotein receptor-related protein (LRP) variations are related to late-onset Alzheimer's disease. However, it remains unclear if genetic polymorphisms in these genes are associated with cognitive decline in late-onset Alzheimer's disease patients. We performed a 30-month longitudinal cohort study to investigate the relationship between Alzheimer's disease and APOE, APOC1, and LRP. In this study, 78 Chinese Han patients with late-onset Alzheimer's disease were recruited form Guangxi Zhuang Autonomous Region in China. APOE, APOC1, and LRP genotyping was performed using polymerase chain reaction-restriction fragment length polymorphisms. The Mini-Mental State Examination and Clinical Dementia Rating Scale were used to assess patients' cognitive function. After a 30-month follow-up period, we found a significant reduction in Mini-Mental State Examination total score, a higher proportion of patients fulfilling cognitive impairment progression criteria, and a higher proportion of APOC1 H2 carriers in APOE ε4 carriers compared with non-carriers. In addition, the APOE ε4 allele frequency was significantly higher in the cognitive impairment progression group compared with the non-cognitive impairment progression group. In conclusion, APOE ε4 plays an important role in augmenting cognitive decline, and APOC1 H2 may act synergistically with APOE ε4 in increasing the risk of cognitive decline in Chinese patients with late-onset Alzheimer's disease.
目前的证据表明载脂蛋白 E（APOE）、载脂蛋白 CI（APOC1）和低密度脂蛋白受体相关蛋白（LRP）的变异与迟发性阿尔茨海默病有关。然而，这些基因中的遗传多态性是否与迟发性阿尔茨海默病患者的认知能力下降有关仍不清楚。我们进行了一项 30 个月的纵向队列研究，以调查阿尔茨海默病与 APOE、APOC1 和 LRP 之间的关系。在这项研究中，我们从中国广西壮族自治区招募了 78 名汉族迟发性阿尔茨海默病患者。采用聚合酶链反应-限制性片段长度多态性技术对 APOE、APOC1 和 LRP 进行基因分型。采用简易精神状态检查和临床痴呆评定量表评估患者的认知功能。经过 30 个月的随访，我们发现 APOE ε4 携带者的简易精神状态检查总分明显下降，符合认知障碍进展标准的患者比例较高，APOC1 H2 携带者比例较高。此外，认知障碍进展组的 APOE ε4 等位基因频率明显高于非认知障碍进展组。总之，APOE ε4 在加速认知能力下降方面起重要作用，APOC1 H2 可能与 APOE ε4 协同作用，增加中国迟发性阿尔茨海默病患者认知能力下降的风险。
Zotero 插件
