丙烯醛作为治疗脊髓损伤运动和感觉功能障碍的新靶点。
Acrolein as a novel therapeutic target for motor and sensory deficits in spinal cord injury.
机构信息
Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA ; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
出版信息
Neural Regen Res. 2014 Apr 1;9(7):677-83. doi: 10.4103/1673-5374.131564.
IN THE HOURS TO WEEKS FOLLOWING TRAUMATIC SPINAL CORD INJURIES (SCI), BIOCHEMICAL PROCESSES ARE INITIATED THAT FURTHER DAMAGE THE TISSUE WITHIN AND SURROUNDING THE INITIAL INJURY SITE: a process termed secondary injury. Acrolein, a highly reactive unsaturated aldehyde, has been shown to play a major role in the secondary injury by contributing significantly to both motor and sensory deficits. In particular, efforts have been made to elucidate the mechanisms of acrolein-mediated damage at the cellular level and the resulting paralysis and neuropathic pain. In this review, we will highlight the recent developments in the understanding of the mechanisms of acrolein in motor and sensory dysfunction in animal models of SCI. We will also discuss the therapeutic benefits of using acrolein scavengers to attenuate acrolein-mediated neuronal damage following SCI.
在创伤性脊髓损伤（SCI）发生后的数小时至数周内，会启动生化过程，进一步损伤初始损伤部位的组织：这一过程称为继发性损伤。丙烯醛是一种高度反应性的不饱和醛，已被证明通过显著导致运动和感觉功能缺陷，在继发性损伤中发挥主要作用。特别是，人们已经努力阐明丙烯醛在细胞水平介导损伤的机制，以及由此导致的瘫痪和神经病理性疼痛。在这篇综述中，我们将重点介绍在动物 SCI 模型中对丙烯醛引起运动和感觉功能障碍的机制的最新研究进展。我们还将讨论使用丙烯醛清除剂来减轻 SCI 后丙烯醛介导的神经元损伤的治疗益处。
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