Anal Chem. 2011 Feb 15;83(4):1197-201. doi: 10.1021/ac103150a. Epub 2011 Jan 19.
Paper spray mass spectrometry (PS-MS) is explored as a fast and convenient way for direct analysis of molecules in tissues with minimum sample pretreatment. This technique allows direct detection of different types of compounds such as hormones, lipids, and therapeutic drugs in short total analysis times (less than 1 min) using a small volume of tissue sample (typically 1 mm(3) or less). The tissue sample could be obtained by needle aspiration biopsy, by punch biopsy, or by rubbing a thin tissue section across the paper. There exists potential for the application of paper spray mass spectrometry together with tissue biopsy for clinical diagnostics.
纸喷雾质谱 (PS-MS) 作为一种快速便捷的方法，用于对组织中的分子进行直接分析，只需进行最小量的样品预处理。该技术允许在较短的总分析时间（不到 1 分钟）内直接检测不同类型的化合物，如激素、脂质和治疗性药物，仅需使用少量的组织样品（通常为 1 立方毫米或更小）。组织样品可以通过针吸活检、切割活检或在纸上摩擦薄组织切片获得。纸喷雾质谱与组织活检结合用于临床诊断具有潜在的应用前景。
