胃癌病理分期与脂质过氧化及转化生长因子-β1水平的关系
Lipid Peroxidation and Transforming Growth Factor-β1 Levels in Gastric Cancer at Pathologic Stages.
机构信息
Clinic of 2 Surgery Clinic, Haseki Training and Research Hospital, İstanbul, Turkey.
Department of Surgery, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey.
出版信息
Balkan Med J. 2012 Sep;29(3):273-6. doi: 10.5152/balkanmedj.2012.026. Epub 2012 Sep 1.
Abstract
OBJECTIVE
High levels of TGF-β1 and enhanced TGF-β1 receptor signaling are related to the pathology of gastric cancer. This effect is caused by oxidative stress and lipid peroxidation products. The aim of this study was to investigate the levels of TGF-β1 and lipid peroxidation products in gastric cancer patients and their correlation with pathologic stage.
MATERIAL AND METHODS
Lipid peroxidation products and TGF-β1 levels were studied in the serum samples of 50 gastric cancer patients and 18 control subjects.
RESULTS
HNE-protein adducts and TGF-β1 levels were significantly higher in T2, T3 and T4 gastric cancers than in either the T1 stage or controls (p<0.001). Pathologic stage was correlated with TGF-β1 levels (r=0.702, p<0.05).
CONCLUSION
These markers production may contribute to tumor angiogenesis and aid in the prognosis of the gastric cancer.
摘要
目的
高水平的 TGF-β1 和增强的 TGF-β1 受体信号与胃癌的病理学有关。这种作用是由氧化应激和脂质过氧化产物引起的。本研究旨在探讨胃癌患者血清中 TGF-β1 和脂质过氧化产物的水平及其与病理分期的相关性。
材料与方法
研究了 50 例胃癌患者和 18 例对照者血清中的脂质过氧化产物和 TGF-β1 水平。
结果
T2、T3 和 T4 期胃癌患者的 HNE-蛋白加合物和 TGF-β1 水平明显高于 T1 期或对照组（p<0.001）。病理分期与 TGF-β1 水平相关（r=0.702，p<0.05）。
结论
这些标志物的产生可能有助于肿瘤血管生成，并有助于胃癌的预后。
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