Department of General Surgery, Kocaeli University School of Medicine, Kocaeli, Turkey.
Department of Medical Biochemistry, Kocaeli University School of Medicine, Kocaeli, Turkey.
Balkan Med J. 2014 Mar;31(1):95-9. doi: 10.5152/balkanmedj.2013.9191. Epub 2014 Mar 1.
It is well known that mucosal changes and alterations in liver function occur in the experimental obstructive jaundice model.
We aimed to evaluate the effect of resveratrol on obstructive jaundice-induced changes in the small bowel mucosa and liver using ischaemia-modified albumin as a marker of oxidative damage.
Animal experimentation.
The study used a rodent experimental model of obstructive jaundice, including a sham group (1), a control group (2), and a study group (3). Wistar albino rats were used. Jaundice was produced by ligation of the bile duct in Groups 2 and 3. In Group 3, resveratrol was administered intraperitoneally for 14 days.
In terms of the structure and the size of the mucosal villi, significant thickening and blunting were detected in Group 2 compared with Group 1. These changes were significantly less noticeable in Group 3 compared with Group 2. Levels of ischaemia-modified albumin were significantly higher in Group 2 compared with those in Group 1, and they were significantly decreased in Group 3 compared with Group 2.
Resveratrol administration to obstructive jaundiced rats reduced the organic effects of obstructive jaundice on small bowel mucosa and liver oxidative stress. We believe that this reduction might attenuate bacterial translocation and systemic effects of secreted cytokines.
众所周知，在实验性梗阻性黄疸模型中会发生黏膜变化和肝功能改变。
我们旨在使用缺血修饰白蛋白作为氧化损伤的标志物来评估白藜芦醇对梗阻性黄疸引起的小肠黏膜和肝脏变化的影响。
动物实验。
本研究使用了梗阻性黄疸的啮齿动物实验模型，包括假手术组（1）、对照组（2）和研究组（3）。使用 Wistar 白化大鼠。第 2 组和第 3 组通过胆管结扎产生黄疸。第 3 组在腹腔内给予白藜芦醇 14 天。
就黏膜绒毛的结构和大小而言，与第 1 组相比，第 2 组明显变厚和变钝。与第 2 组相比，第 3 组的这些变化明显不那么明显。与第 1 组相比，第 2 组的缺血修饰白蛋白水平明显升高，与第 2 组相比，第 3 组明显降低。
给予梗阻性黄疸大鼠白藜芦醇可减轻梗阻性黄疸对小肠黏膜和肝脏氧化应激的有机影响。我们认为，这种减少可能会减轻细菌易位和分泌细胞因子的全身效应。
