Department of Medical Oncology, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir, Turkey.
Department of Medical Oncology, Konya Training and Research Hospital, Konya, Turkey.
Balkan Med J. 2014 Jun;31(2):126-31. doi: 10.5152/balkanmedj.2014.13143. Epub 2014 Jun 1.
Triple-negative (TN) breast cancer is a subtype of breast cancer characterised by a loss of estrogen receptor (ER), progesterone receptor (PR) expression, and the absence of human epidermal growth factor (HER2) overexpression.
To identify the relationships between clinicopathological characteristics of TN breast cancers in the northeast region of Turkey and disease free survival (DFS) and overall survival (OS).
Retrospective clinical study.
Seven hundred and eighty non-metastatic breast cancer patients were enrolled in this study. The relationships between TN breast cancer and other breast cancers with respect to clinicopathological characteristics, as well as DFS and OS, were studied.
The triple-negative phenotype was detected in 204 patients (27.1%). Patients with triple-negative breast cancer had more grade 2-3 tumours compared to those with other types of breast cancer (92.5% versus 84.3%, p=0.004). Invasive ductal carcinoma histology, on the other hand, was less prevalent in patients with TN breast cancer (77% versus 84.5%, p=0.016). No significant differences were identified between the groups in other clinicopathological variables. Relapse and mortality rates were higher in the TN group during the follow-up of both groups [57 (27.9%) versus 89 (16.2%), p<0.001 for relapse; 27 (13.2%) versus 37 (6.8%), p=0.005 for mortality]. The univariate analysis demonstrated shorter DFS and OS for patients with TN breast cancer compared to those with other types of breast cancer. In the multivariate analysis, patients with TN breast cancer were 2.21 times more likely to develop relapse, while the likelihood of death increased 3.21-fold (p<0.001 and p<0.001).
Triple-negative breast cancers demonstrate a more aggressive clinical course compared to other breast cancers. More effective strategies should be developed for the treatment of this subgroup of breast cancer.
三阴性（TN）乳腺癌是一种乳腺癌亚型，其特征是雌激素受体（ER）、孕激素受体（PR）表达缺失，以及人表皮生长因子（HER2）过表达缺失。
确定土耳其东北部地区 TN 乳腺癌的临床病理特征与无病生存（DFS）和总生存（OS）之间的关系。
回顾性临床研究。
本研究纳入了 780 例非转移性乳腺癌患者。研究了 TN 乳腺癌与其他乳腺癌在临床病理特征以及 DFS 和 OS 方面的关系。
204 例（27.1%）患者为三阴性表型。与其他类型的乳腺癌相比，TN 乳腺癌患者的肿瘤分级 2-3 级更多（92.5%比 84.3%，p=0.004）。另一方面，TN 乳腺癌患者中浸润性导管癌组织学较少见（77%比 84.5%，p=0.016）。两组在其他临床病理变量方面无显著差异。在两组的随访期间，TN 组的复发和死亡率均较高[57（27.9%）比 89（16.2%），p<0.001 用于复发；27（13.2%）比 37（6.8%），p=0.005 用于死亡]。单因素分析表明，与其他类型的乳腺癌相比，TN 乳腺癌患者的 DFS 和 OS 更短。在多因素分析中，与其他类型乳腺癌患者相比，TN 乳腺癌患者发生复发的可能性增加了 2.21 倍，而死亡的可能性增加了 3.21 倍（p<0.001 和 p<0.001）。
与其他乳腺癌相比，TN 乳腺癌表现出更具侵袭性的临床过程。应该为治疗这一乳腺癌亚组制定更有效的策略。
