Heidari-Bateni Giv, Brar Anoop K, Hall Matthew, Hathcock Trupti, Epstein Deirdre, Goessling Lisa S, Cunningham Madeleine W, Eghtesady Pirooz
Division of Pediatric Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Children's Hospital Association, 6803 West 64th Street, Overland Park, KS 66202, USA.
Infect Dis Obstet Gynecol. 2014;2014:639141. doi: 10.1155/2014/639141. Epub 2014 Aug 20.
To report the pharyngeal colonization rate of β-hemolytic streptococci and changes in the value of antistreptolysin O (ASO) and anti-DNase B serology titers during pregnancy.
Healthy pregnant women were recruited and blood was drawn in each trimester. The upper limit of normal (ULN) values for ASO and anti-DNase B was calculated for each trimester. Throat swabs were collected for culture and positive cultures were further assessed for the identification of serogroup of the isolated β-hemolytic streptococcus.
Out of a total of 126 pregnant women, 34.1% had positive throat cultures. Group C and group G strains were isolated in 18.2% of throat cultures while group F was detected in 13.5% of cases. The rate of colonization with GAS was 1.6%. There was an overall drop in ASO titer during pregnancy while anti-DNase B titers remained relatively unchanged. ULN values of 164(IU), 157(IU), and 156(IU) were calculated for ASO at the first, second, and third trimesters, respectively. Based on the ULN values, 28.6% of patients had recent streptococcal exposure.
These results show that pregnant women act as a reservoir for spreading potentially immunogenic (groups C and G) and disease producing (group F) virulent strains of streptococci.
报告孕期β溶血性链球菌的咽部定植率以及抗链球菌溶血素O（ASO）和抗脱氧核糖核酸酶B血清学滴度值的变化。
招募健康孕妇，在每个孕期采集血液。计算每个孕期ASO和抗脱氧核糖核酸酶B的正常上限（ULN）值。采集咽拭子进行培养，对阳性培养物进一步评估以鉴定分离出的β溶血性链球菌的血清群。
在总共126名孕妇中，34.1%的咽拭子培养呈阳性。18.2%的咽拭子培养分离出C组和G组菌株，13.5%的病例检测到F组。A组链球菌（GAS）的定植率为1.6%。孕期ASO滴度总体下降，而抗脱氧核糖核酸酶B滴度相对保持不变。第一、第二和第三孕期ASO的ULN值分别计算为164（IU）、157（IU）和156（IU）。根据ULN值，28.6%的患者近期有链球菌暴露。
这些结果表明，孕妇是潜在免疫原性（C组和G组）和致病（F组）毒力链球菌传播的储存宿主。
