Hines R
Department of Anesthesiology, Yale University School of Medicine, Yale-New Haven Hospital, CT 06510.
J Cardiothorac Anesth. 1989 Dec;3(6 Suppl 2):24-32. doi: 10.1016/0888-6296(89)90056-2.
A bipyridine derivative, amrinone is a noncatecholamine, nonglycoside alternative in the treatment of perioperative myocardial dysfunction. A type-3 phosphodiesterase enzyme inhibitor, amrinone combines positive inotropic support with systemic and pulmonary vasodilation. In patients with heart failure undergoing cardiac or noncardiac surgery, the absence of tachycardia and dysrhythmias is of particular clinical benefit. In these patients, amrinone's ability to augment cardiac performance without increasing heart rate or myocardial oxygen consumption offers significant clinical advantages during the perioperative period.
氨力农是一种联吡啶衍生物，属于非儿茶酚胺类、非糖苷类药物，用于治疗围手术期心肌功能障碍。作为一种3型磷酸二酯酶抑制剂，氨力农兼具正性肌力作用及全身和肺血管舒张作用。对于接受心脏手术或非心脏手术的心力衰竭患者，不出现心动过速和心律失常具有特别的临床益处。在这些患者中，氨力农增强心脏功能而不增加心率或心肌耗氧量的能力在围手术期具有显著的临床优势。
