肾素-血管紧张素系统基因多态性在肾脏疾病中的作用：荟萃分析。
The role of genetic polymorphisms of the Renin-Angiotensin System in renal diseases: A meta-analysis.
机构信息
Department of Computer Science and Biomedical Informatics, University of Thessaly, Lamia 35100, Greece.
出版信息
Comput Struct Biotechnol J. 2014 Jun 11;10(16):1-7. doi: 10.1016/j.csbj.2014.05.006. eCollection 2014 Jun.
Abstract
Renal failure has a complex phenotype resulting from an underlying kidney disease as well as environmental and genetic factors. In the present study we performed a systematic review and meta-analyses to evaluate the association of the A1166C polymorphism of Angiotensin II type 1 Receptor gene (AGTR1) with Chronic Kidney Disease (CKD), End Stage Renal Disease (ESRD), IgA Nephropathy (IgAN) and Vesicoureteral Reflux (VUR) as well as the association of A1332G polymorphism of Angiotensin II type 2 Receptor (AGTR2) gene with Vesicoureteral Reflux (VUR). We found that neither AGTR1 Α1166C, nor AGTR2 A1332G polymorphisms were significantly associated with any of the aforementioned renal diseases, suggesting that they cannot be used as predictive markers in either general or subgroup ethnic populations.
摘要
肾衰竭的表型复杂，由潜在的肾脏疾病以及环境和遗传因素共同导致。在本研究中，我们进行了系统评价和荟萃分析，以评估血管紧张素 II 型 1 受体（AGTR1）基因的 A1166C 多态性与慢性肾脏病（CKD）、终末期肾病（ESRD）、IgA 肾病（IgAN）和膀胱输尿管反流（VUR）的关联，以及血管紧张素 II 型 2 受体（AGTR2）基因的 A1332G 多态性与膀胱输尿管反流（VUR）的关联。我们发现，AGTR1 Α1166C 或 AGTR2 A1332G 多态性与上述任何一种肾脏疾病均无显著相关性，提示其不能作为一般或亚组人群的预测标志物。
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