Starkstein S E, Bolduc P L, Preziosi T J, Robinson R G
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
J Neuropsychiatry Clin Neurosci. 1989 Summer;1(3):243-8. doi: 10.1176/jnp.1.3.243.
A consecutive series of 94 patients with Parkinson's disease (PD) were evaluated for the presence of depression and neuropsychological deficits. Patients were divided into groups based on the severity of their PD symptoms and then further subdivided into depressed and nondepressed groups. Both stage of PD and existence of depression had significant effects on neuropsychological performance. The nondepressed group with severe symptoms showed deficits in cognitive tasks involving motor speed, and the depressed patients with severe symptoms demonstrated impairments in frontal-lobe-related tasks.
对连续的94例帕金森病（PD）患者进行了抑郁和神经心理缺陷的评估。根据PD症状的严重程度将患者分组，然后进一步细分为抑郁组和非抑郁组。PD的阶段和抑郁的存在对神经心理表现均有显著影响。症状严重的非抑郁组在涉及运动速度的认知任务中存在缺陷，而症状严重的抑郁患者在与额叶相关的任务中表现受损。
