Department of Psychology, Fairleigh Dickinson University, Teaneck, NJ, USA.
Arch Clin Neuropsychol. 2014 Feb;29(1):110-20. doi: 10.1093/arclin/act071. Epub 2013 Sep 9.
Apathy is associated with impaired neuropsychological functioning in individuals with HIV. While cognitive reserve (CR) delays neurocognitive decline, CR's relationship with apathy has never been studied. We examined CR's association with apathy in 116 HIV-positive individuals recruited from an urban AIDS center and assessed whether this relationship is moderated by age and/or disease severity. Participants completed the Wechsler Test of Adult Reading and Apathy Evaluation Scale. A CR-composite, combining years of education and word-reading ability, significantly predicted apathy (t = -2.37, p = .02). CR's relationship with apathy was not moderated by age, but participants with nadir CD4 levels ≤ 200 demonstrated a stronger association (t = -3.25, p = .002) than those with nadir CD4 levels > 200 (t = -0.61, p = .55). These findings suggest a protective effect of CR against apathy in HIV-infected individuals across the age span, particularly after a certain threshold of disease severity.
淡漠与 HIV 感染者的神经心理功能受损有关。虽然认知储备（CR）可以延缓认知能力下降，但 CR 与淡漠之间的关系尚未得到研究。我们研究了 116 名从城市艾滋病中心招募的 HIV 阳性个体的 CR 与淡漠之间的关系，并评估了这种关系是否受年龄和/或疾病严重程度的影响。参与者完成了韦氏成人阅读测验和淡漠评估量表。CR 综合了教育年限和阅读能力，显著预测了淡漠（t=-2.37，p=.02）。CR 与淡漠的关系不受年龄影响，但 CD4 最低水平≤200 的参与者的关联比 CD4 最低水平>200 的参与者更强（t=-3.25，p=.002，t=-0.61，p=.55）。这些发现表明，CR 在整个年龄范围内对 HIV 感染者的淡漠具有保护作用，尤其是在疾病严重程度达到一定阈值后。
