进行性核上性麻痹中的脑铁：临床、磁共振成像及神经病理学发现
Brain iron in progressive supranuclear palsy: clinical, magnetic resonance imaging, and neuropathological findings.
作者信息
Coffey C E, Alston S, Heinz E R, Burger P C
机构信息
Department of Medicine (Neurology), Duke University Medical Center, Durham, NC 27710.
出版信息
J Neuropsychiatry Clin Neurosci. 1989 Fall;1(4):400-4. doi: 10.1176/jnp.1.4.400.
PMID:2521091
Abstract
A patient with progressive supranuclear palsy demonstrated a region-specific decrease in T2 signal during high-field-strength brain magnetic resonance imaging. At autopsy the T2-signal hypointensity was found to correspond topographically to increased deposition of ferric iron. The potential clinical, radiologic, and pathophysiologic implications of these findings are discussed.
摘要
一名进行性核上性麻痹患者在高场强脑磁共振成像期间显示出T2信号的区域特异性降低。尸检时发现T2信号低强度在地形上与三价铁沉积增加相对应。讨论了这些发现潜在的临床、放射学和病理生理学意义。
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