Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA; Robert Lurie Comprehensive Cancer Center, Northwestern University, Evanston, IL 60208, USA.
Cell Host Microbe. 2014 Sep 10;16(3):271-2. doi: 10.1016/j.chom.2014.08.016.
Planarians famously can regenerate after decapitation. In this issue, Abnave et al. (2014) find they resist infection by multiple bacterial species pathogenic to humans, Drosophila and C. elegans, including M. tuberculosis. These results identify a conserved gene controlling phagocytosis and establish planarians as a powerful system for analyzing host-pathogen interactions.
涡虫在被斩首后能够再生,这是众所周知的。在本期杂志中,Abnave 等人(2014 年)发现,它们能够抵抗多种对人类、果蝇和秀丽隐杆线虫等生物体致病的细菌感染,包括结核分枝杆菌。这些结果鉴定出一个控制吞噬作用的保守基因,并确立了涡虫作为分析宿主-病原体相互作用的强大系统。