Abribat T, Regnier A, Morre M
Zentralbl Veterinarmed A. 1989 May;36(5):367-73. doi: 10.1111/j.1439-0442.1989.tb00742.x.
The growth hormone (GH) secretory response to varying doses (1, 5 and 25 micrograms/kg) of intravenous (i.v.) human GH releasing factor (GRF) (1-44) was measured in four, 16-month-old female dogs and compared to the GH response to placebo (vehicle solubilizing GRF) and standard clonidine test (10 micrograms/kg i.v.). The three doses of GRF had no apparent clinical side effects and were capable of eliciting a rapid increase in the mean plasma GH level. The rise in plasma GH occurred within 5 minutes with a peak response at 15-30 minutes. However inter-subject variability of the GH response was large in terms of magnitude and time course. By analysis of the areas under the response curves it was shown that GRF 1-44 was as effective in stimulating GH release as clonidine and that a dose of 1 microgram/kg GRF 1-44 could be a good choice for use as a standard test dose in the dog.
在4只16月龄的雌性犬中，测量了静脉注射不同剂量（1、5和25微克/千克）人生长激素释放因子（GRF）（1-44）后生长激素（GH）的分泌反应，并将其与GH对安慰剂（溶解GRF的赋形剂）和标准可乐定试验（静脉注射10微克/千克）的反应进行比较。三种剂量的GRF均无明显临床副作用，且能够使平均血浆GH水平迅速升高。血浆GH在5分钟内升高，在15-30分钟时达到峰值反应。然而，GH反应在幅度和时间进程方面的个体间变异性很大。通过分析反应曲线下的面积表明，GRF 1-44在刺激GH释放方面与可乐定一样有效，并且1微克/千克的GRF 1-44剂量可能是犬类标准试验剂量的良好选择。
