开发用于控制全球结核病流行的疫苗。
Development of vaccines to control the worldwide tuberculosis pandemic.
作者信息
Hoft Daniel F
出版信息
Mo Med. 2014 Jul-Aug;111(4):326-31.
Abstract
Mycobacterium tuberculosis (Mtb) infection and tuberculosis (TB) disease are major public health problems. Available BCG vaccines are partially effective against severe disease, but have not reduced the overall prevalence of TB infection and disease. A third of the world's population is latently infected with Mtb, and therefore more effective prophylactic and therapeutic vaccines are urgently needed. The Hoft laboratory and the Saint Louis University Center for Vaccine Development (SLUCVD) are actively pursuing these important goals.
摘要
结核分枝杆菌（Mtb）感染和结核病是主要的公共卫生问题。现有的卡介苗（BCG）对重症疾病有部分疗效，但并未降低结核感染和疾病的总体患病率。全球三分之一的人口潜伏感染结核分枝杆菌，因此迫切需要更有效的预防性和治疗性疫苗。霍夫特实验室和圣路易斯大学疫苗开发中心（SLUCVD）正在积极追求这些重要目标。
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