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N-Acetylcysteine for thrombotic thrombocytopenic purpura: is a von Willebrand factor-inhibitory dose feasible in vivo?

作者信息

Shortt Jake, Opat Stephen S, Wood Erica M

机构信息

Monash Haematology, Monash University, Clayton, Victoria, Australia; Southern Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia.

出版信息

Transfusion. 2014 Sep;54(9):2362-3. doi: 10.1111/trf.12787.

DOI:10.1111/trf.12787
PMID:25212426
Abstract
摘要

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2
The antioxidant N-acetylcysteine promotes immune response and inhibits epithelial-mesenchymal transition to alleviate pulmonary fibrosis in chronic obstructive pulmonary disease by suppressing the VWF/p38 MAPK axis.抗氧化剂 N-乙酰半胱氨酸通过抑制 VWF/p38 MAPK 轴促进免疫反应并抑制上皮-间充质转化,从而减轻慢性阻塞性肺疾病中的肺纤维化。
Mol Med. 2021 Sep 3;27(1):97. doi: 10.1186/s10020-021-00342-y.
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The role of von Willebrand factor in thrombotic microangiopathy.
血管性血友病因子在血栓性微血管病中的作用。
Pediatr Nephrol. 2018 Aug;33(8):1297-1307. doi: 10.1007/s00467-017-3744-y. Epub 2017 Jul 26.
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The role of N-acetylcysteine in the treatment of thrombotic thrombocytopenic purpura.N-乙酰半胱氨酸在血栓性血小板减少性紫癜治疗中的作用。
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