Centro de Reconocimiento Molecular y Desarrollo (IDM), UPV-UV, Camino de Vera, 46022 Valencia (Spain).
Angew Chem Int Ed Engl. 2014 Nov 3;53(45):12106-10. doi: 10.1002/anie.201407005. Epub 2014 Sep 11.
There is large interest in replicating biological supramolecular structures in inorganic materials that are capable of mimicking biological properties. The use of 5-guanosine monophosphate in the presence of Na(+) and K(+) ions as a supramolecular template for the synthesis of well-ordered mesostructured materials is reported here. Mesostructured particles with the confined template exhibit high structural order at both meso- and atomic scales, with a lower structural symmetry in the columnar mesophase. Although a chiral space group can not be deduced from X-ray diffraction, analysis by electron microscopy and circular dichroism confirms a chiral stacking arrangement along the c-axis. Guanosine monophosphate based mesophases thus illustrate the possibility for specific molecular imprinting of mesoporous materials by genetic material and the potential for higher definition in molecular recognition.
人们对复制具有生物特性的无机材料中的生物超分子结构很感兴趣。本文报道了在 Na(+)和 K(+)离子存在下，5-鸟苷一磷酸作为合成有序介孔材料的超分子模板的应用。具有受限模板的介孔颗粒在介观和原子尺度上均表现出高结构有序性，而柱状介相中的结构对称性较低。尽管无法从 X 射线衍射中推断出手性空间群，但电子显微镜和圆二色性分析证实了沿 c 轴的手性堆积排列。基于鸟苷一磷酸的介相因此说明了通过遗传物质对介孔材料进行特定分子印迹的可能性，以及在分子识别中实现更高分辨率的可能性。
