Prucktrakul Chalakorn, Youngnak-Piboonratanakit Pornpan, Kanjanabuch Patnarin, Prueksrisakul Titipong, Thongprasom Kobkan
Oral Medicine Department, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
J Oral Pathol Med. 2015 Jul;44(6):468-74. doi: 10.1111/jop.12257. Epub 2014 Sep 12.
The aim of this study was to investigate the presence of serum antinuclear antibodies (ANA) in Thai oral lichenoid drug reaction (OLDR) and oral lichen planus (OLP) patients.
This study comprised 20 patients diagnosed with OLDR, 23 patients with OLP, and 24 healthy control subjects. Participants' blood samples were assayed for ANA staining patterns and serum ANA titer levels by immunofluorescence using human epithelial type 2 (HEp-2) as a substrate. The serum ANA titer levels were defined as low (1:40-1:80), medium (1:160-1:320), and high (>1:640).
Serum ANA were detected in 73.9%, 70%, and 25% of OLP, OLDR, and control subjects, respectively. There was a statistically significant difference between the number of serum-ANA-positive subjects in the OLP or OLDR groups and the control group (P < 0.01), but no significant difference between the OLP and OLDR groups. The speckled pattern was the most commonly found staining pattern, present in 60.9%, 55.0%, and 20.8% of the OLP, OLDR, and control subjects, respectively. The number of subjects with low ANA titers in the OLP and OLDR groups was significantly higher than that of the control group (P < 0.01). Medium ANA titers were found in 15%, 4.4%, and 4.2% of the OLDR, OLP, and control subjects, respectively, while high ANA titers were not found in any group.
The number of serum-ANA-positive OLP and OLDR patients was significantly higher than the control group. Speckled pattern and low titer levels were the most common findings in both OLP and OLDR groups.
本研究旨在调查泰国口腔苔藓样药物反应（OLDR）和口腔扁平苔藓（OLP）患者血清抗核抗体（ANA）的存在情况。
本研究包括20例诊断为OLDR的患者、23例OLP患者和24例健康对照者。采用以人上皮2型（HEp-2）为底物的免疫荧光法检测参与者血液样本的ANA染色模式和血清ANA滴度水平。血清ANA滴度水平分为低（1:40 - 1:80）、中（1:160 - 1:320）和高（>1:640）。
分别在73.9%的OLP患者、70%的OLDR患者和25%的对照者中检测到血清ANA。OLP或OLDR组血清ANA阳性受试者数量与对照组之间存在统计学显著差异（P < 0.01），但OLP组和OLDR组之间无显著差异。斑点型是最常见的染色模式，分别在60.9%的OLP患者、55.0%的OLDR患者和20.8%的对照者中出现。OLP组和OLDR组中ANA滴度低的受试者数量显著高于对照组（P < 0.01）。分别在15%的OLDR患者、4.4%的OLP患者和4.2%的对照者中发现中等ANA滴度，而任何组均未发现高ANA滴度。
血清ANA阳性的OLP和OLDR患者数量显著高于对照组。斑点型和低滴度水平是OLP组和OLDR组中最常见的发现。
