Kraft H G, Menzel H J, Hoppichler F, Vogel W, Utermann G
Institute of Medical Biology and Genetics, University of Innsbruck, Austria.
J Clin Invest. 1989 Jan;83(1):137-42. doi: 10.1172/JCI113849.
Liver transplantation provides a unique opportunity to investigate the contribution in vivo of the liver to the synthesis and degradation of genetically polymorphic plasma proteins. We have determined the genetic polymorphisms plasma proteins. We have determined the genetic polymorphisms of apo A-IV, apo E, and of the Lp(a) glycoprotein (apo (a] in the plasma of subjects undergoing liver transplantation and in respective organ donors. The results show that in humans, greater than 90% of the plasma apo E and virtually all apo (a) are liver derived, whereas this organ does not significantly contribute to plasma apo A-IV levels.
肝移植为研究肝脏在体内对遗传多态性血浆蛋白合成和降解的贡献提供了独特的机会。我们已经确定了血浆蛋白的遗传多态性。我们测定了肝移植受者及其相应器官供者血浆中载脂蛋白A-IV、载脂蛋白E和脂蛋白(a)糖蛋白（载脂蛋白(a)）的遗传多态性。结果表明，在人类中，超过90%的血浆载脂蛋白E和几乎所有的载脂蛋白(a)都来源于肝脏，而该器官对血浆载脂蛋白A-IV水平的贡献并不显著。
