肝功能损害患者发生他汀类药物诱导的横纹肌溶解症的风险。
Risk of statin-induced rhabdomyolysis in patients with hepatic impairment.
作者信息
Kolhe Nitin, Lewis Jeremy, McCulloch Thomas Alasdair
机构信息
Renal Unit, Royal Derby Hospital, Derby, UK.
Department of Histopathology, Nottingham University Hospitals NHS Trust, Nottingham, UK.
出版信息
BMJ Case Rep. 2014 Sep 11;2014:bcr2014204013. doi: 10.1136/bcr-2014-204013.
We describe a case of a 54-year-old man with a 2-month history of biliary colic associated with a common bile duct stone. He underwent laparoscopic cholecystectomy and developed postoperative acute kidney injury stage 3. A renal biopsy was performed and demonstrated myoglobin in the renal tubules. Retrospective creatine kinase analysis was suggestive of rhabdomyolysis. It is thought this was precipitated by simvastatin accumulation in the context of a period of hepatic impairment and elevated liver enzymes.
我们描述了一例54岁男性患者，有2个月与胆总管结石相关的胆绞痛病史。他接受了腹腔镜胆囊切除术，术后出现3期急性肾损伤。进行了肾活检，结果显示肾小管中有肌红蛋白。回顾性肌酸激酶分析提示存在横纹肌溶解。据认为，这是在肝功能损害和肝酶升高期间辛伐他汀蓄积所致。
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