Senthilkumar B, Sathasivasubramanian S
Department of Oral Medicine and Radiology, K. S. R Institute of Dental Science and Research, Trichengode, Namakkal District, Tamil Nadu, India.
Department of Oral Medicine and Radiology, Sri Ramachandra Dental College and Hospital, Chennai, Tamil Nadu, India.
World J Nucl Med. 2013 Sep;12(3):94-100. doi: 10.4103/1450-1147.136733.
The aim of the present study was to evaluate the salivary gland dysfunction in patients with uncontrolled type II diabetes using salivary gland scintigraphy and then to compare these ratios with quantitative whole salivary secretion rates. Using a gamma camera (siemens-diacam) equipped with a low energy all-purpose collimator, 32 uncontrolled type II diabetic patients and 30 normal healthy patients were studied by injecting a radio isotope (technetium 99m pertechnetate) about 5 mCi was injected intravenously in to anticubital vein and the activity was measured for the 1(st), 20(th) and 40(th) min. At 20 min after injection, vitamin C chewable tablet was given to stimulate the secretion and continued until the end of the study period (40 min). Before scintigraphy, salivary sampling was carried out in both diabetic and normal individuals in a quiet room, saliva was allowed to accumulate and was expectorated into the collecting vessel approximately once a minute for 15 min and the volume was recorded as Unstimulated salivary flow rate and after 5 min break vitamin C chewable tablet was given to stimulate the secretion and the patient was asked to expectorate the saliva in the collecting vessel for 5 min. The expectorated volume was recorded as stimulated salivary flow rate. The mean of the measurements of scintigraphic ratio and salivary secretion rates were compared using the paired Student's t-test. The scintigraphic mean uptake and excretory ratio (ER) and the salivary flow rates were correlated. The result shows that there was a significant correlation between salivary flow rate and scintigraphic uptake and ER. However, statistically significant result could not be derived as it may be due to smaller sample size and marginal difference in the scintigraphic values between the groups. Salivary gland scintigraphy plays a significant role in the evaluation of salivary gland dysfunction. However, its role as an independent investigative procedure in the evaluation of salivary gland dysfunction requires a study with a larger sample size, may yield a statistical significant result and it can also act as an adjunct along with salivary flow rate procedure.
本研究的目的是使用唾液腺闪烁扫描术评估未控制的II型糖尿病患者的唾液腺功能障碍，然后将这些比率与定量全唾液分泌率进行比较。使用配备低能通用准直器的γ相机（西门子 - 迪卡姆），对32例未控制的II型糖尿病患者和30例正常健康患者进行研究，通过将约5毫居里的放射性同位素（高锝酸盐99m锝）静脉注射到肘前静脉，并在第1、20和40分钟测量活性。注射后20分钟，给予维生素C咀嚼片以刺激分泌，并持续至研究期结束（40分钟）。在闪烁扫描术前，在安静的房间里对糖尿病患者和正常个体进行唾液采样，让唾液积聚，大约每分钟向收集容器中咳出一次，持续15分钟，记录该体积为未刺激唾液流速，休息5分钟后给予维生素C咀嚼片以刺激分泌，并要求患者在收集容器中咳出唾液5分钟。记录咳出的体积为刺激唾液流速。使用配对学生t检验比较闪烁扫描比率和唾液分泌率测量值的平均值。闪烁扫描平均摄取和排泄率（ER）与唾液流速相关。结果表明唾液流速与闪烁扫描摄取和ER之间存在显著相关性。然而，由于样本量较小以及两组之间闪烁扫描值的差异较小，未能得出具有统计学意义的结果。唾液腺闪烁扫描术在评估唾液腺功能障碍方面发挥着重要作用。然而，其作为评估唾液腺功能障碍的独立检查程序的作用需要进行更大样本量的研究，可能会得出具有统计学意义的结果，并且它也可以作为唾液流速检查程序的辅助手段。
