Driesen Annelies, Simoens Steven, Laekeman Gert
Research Centre for Pharmaceutical Care and Pharmaco-economics, Katholieke Universiteit Leuven , ( Belgium ).
Pharm Pract (Granada). 2006;4(3):143-50.
There is a lack of clear guidelines regarding the management of drug-drug interactions.
To assess the impact of an educational intervention on the management of drug interactions with beta-blockers.
The study had a controlled before-and-after design. The intervention group (n=10 pharmacies) received a continuing education course and guidelines on the management of drug interactions with beta-blockers. The control group (n=10 pharmacies) received no intervention. Pharmacy students and staff of internship pharmacies participated in this study. Before and after the intervention, students registered interactions with beta-blockers during two weeks. Information was obtained on drug information of the beta-blocker and the interacting drug, patient's demographics, and the mode of transaction.
A total number of 288 interactions were detected during both study periods. Most beta-blockers causing an interaction were prescribed for hypertension, and interacted with hypoglycemic agents, NSAIDs, or beta2-agonists. Pharmacists' intervention rate was low (14% in the pre-test compared to 39% in the post-test), but increased significantly in the post-test in the intervention group. Reasons for overriding the interaction included limited clinical relevance, refill prescriptions, not being aware of the interaction, and communication problems with the prescriber.
An interactive continuing education course, during which practice-oriented guidelines were offered, affected pharmacists' short-term behavior at the counter in dealing with interactions of beta-blockers. Continuing education plays a role in raising pharmacists' awareness and responsibility towards the detection and management of drug interactions in the pharmacy.
关于药物相互作用的管理缺乏明确的指南。
评估一项教育干预措施对β受体阻滞剂药物相互作用管理的影响。
本研究采用前后对照设计。干预组（n = 10家药房）接受了关于β受体阻滞剂药物相互作用管理的继续教育课程和指南。对照组（n = 10家药房）未接受干预。实习药房的药学专业学生和工作人员参与了本研究。在干预前后，学生们记录了两周内与β受体阻滞剂的相互作用情况。获取了有关β受体阻滞剂和相互作用药物的药物信息、患者人口统计学数据以及交易方式的信息。
在两个研究阶段共检测到288例相互作用。大多数引起相互作用的β受体阻滞剂用于治疗高血压，且与降糖药、非甾体抗炎药或β2激动剂发生相互作用。药剂师的干预率较低（预测试中为14%，而测试后为39%），但在干预组中测试后的干预率显著提高。忽视相互作用的原因包括临床相关性有限、续方、未意识到相互作用以及与开处方者的沟通问题。
提供了以实践为导向的指南的互动式继续教育课程影响了药剂师在柜台处理β受体阻滞剂相互作用时的短期行为。继续教育在提高药剂师对药房中药物相互作用的检测和管理的认识及责任感方面发挥了作用。
