贯叶连翘提取物对不稳定型心绞痛老年患者抑郁障碍的影响。

Effect of St. John's wort extract on depressive disorder in elderly patients with unstable angina.

机构信息

Department of Emergency Medicine, the Second Hospital, Tianjin Medical University, Tianjin 300211, China.

出版信息

World J Emerg Med. 2010;1(1):41-4.

PMID:25214939

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4129765/

Abstract

BACKGROUND

The elderly patients with coronary heart disease (CHD) are often accompanied with depression. This study aimed to assess the effect of St. John's wort extract (SWE) on depressive disorder in elderly patients with unstable angina pectoris.

METHODS

Altogether 170 patients who met the set criteria were enrolled in this prospective study. They were randomly divided into SWE group (44 patients), Deanxit group (44), psychotherapy group (42), and control group (40). The effectiveness of SWE was evaluated by reduced percentage of Hamilton depression (HAMD) scale and reduced frequency of angina pectoris attack, which were measured before and at 12 weeks after the treatment with SWE.

RESULTS

The reduced percentages of HAMD scale were 79.5%, 56.8% and 57.1% in the SWE, Deanxit and psychotherapy groups, respectively. Compared with the control, the three groups had significant differences in the percentages (P<0.001). The improvement after the treatment was more significant in the SWE group than in the Deanxit or psychotherapy group (P<0.05). The improvement of angina pectoris evaluated by the Canadian Cardiac Society Classification was significantly better in the treatment groups (88. 7%, 65. 9%, 57.1%) than in the control group, and it was marked in the SWE group (P<0.001). Angina pectoris attack, its frequencies, durations and electrocardiographic changes were significantly improved in the treatment groups than in the control group (F=6.05, 4.58, 5.12, P<0.01). They are markedly improved in the SWE group (P<0.05).

CONCLUSION

SWE can improve depressive symptoms more significantly in elderly patients with unstable angina pectoris than Deanxit or psychotherapy, proving that SWE contributes to better treatment of angina attack as well.

摘要

背景

冠心病（CHD）老年患者常伴有抑郁。本研究旨在评估贯叶连翘提取物（SWE）对不稳定型心绞痛老年患者抑郁障碍的影响。

方法

共纳入符合标准的 170 例患者，前瞻性研究。随机分为 SWE 组（44 例）、黛安神组（44 例）、心理治疗组（42 例）和对照组（40 例）。治疗后 12 周采用汉密尔顿抑郁量表（HAMD）评分降低率和心绞痛发作频率评估 SWE 的疗效。

结果

SWE、黛安神和心理治疗组 HAMD 量表评分降低率分别为 79.5%、56.8%和 57.1%。与对照组相比，三组差异有统计学意义（P<0.001）。SWE 组治疗后改善程度优于黛安神组或心理治疗组（P<0.05）。加拿大心脏病学会分级评定的心绞痛改善在治疗组（88.7%、65.9%、57.1%）明显优于对照组，SWE 组改善明显（P<0.001）。与对照组相比，治疗组心绞痛发作、发作频率、持续时间和心电图变化均明显改善（F=6.05、4.58、5.12，P<0.01）。SWE 组改善明显（P<0.05）。