雾化吸入利多卡因治疗急性哮喘患者。
Nebulized lidocaine inhalation in the treatment of patients with acute asthma.
机构信息
Intensive Care Unit, Third People's Hospital of Chongqing, Chongqing 400014, China (Lv ZM, Tang J); Experimental Teaching Center of Chongqing Medical University, Chongqing 400016, China (Chen L).
出版信息
World J Emerg Med. 2011;2(1):30-2.
BACKGROUND
Lidocaine can promote the apoptosis of eosinophils, which is normally delayed by IL-5; it has a good effect on serious steroid resistant asthma (SRA). The study aimed to explore the effect of nebulized lidocaine inhalation on asthma.
METHODS
It was a randomized, double-blind, placebo-controlled and prospective study. A total of 36 patients with acute asthma were divided into groups A1, A2, B1 and B2, with 9 patients in each group. The patients of groups A1 and A2 had steroid resistant asthma (SRA) and those of groups B1 and B2 had steroid sensitive asthma (SSA). Patients in groups A2 and B1 were administered nebulized lidocaine in addition to routine treatment, while patients in groups A1 and B2 were given nebulized normal saline apart from routine treatment and served as placebo-controlled groups.
RESULTS
There were significant differences in heart rate, respiratory rate, and peak flow rate and forced expiratory volume in one second between the experimental groups and the placebo-controlled groups. There was no significant difference between groups A2 and B1, and between A1 and B2.
CONCLUSION
Inhaled lidocaine is beneficial to asthma patients, especially those with steroid-resistant asthma.
背景
利多卡因可促进嗜酸性粒细胞凋亡，而白细胞介素-5 会延迟这一过程；它对严重的激素抵抗性哮喘（SRA）有很好的疗效。本研究旨在探讨雾化吸入利多卡因对哮喘的影响。
方法
这是一项随机、双盲、安慰剂对照的前瞻性研究。共纳入 36 例急性哮喘患者，分为 A1、A2、B1 和 B2 组，每组 9 例。A1 和 A2 组患者为激素抵抗性哮喘（SRA），B1 和 B2 组患者为激素敏感性哮喘（SSA）。A2 和 B1 组患者在常规治疗的基础上给予雾化利多卡因，A1 和 B2 组患者除常规治疗外还给予雾化生理盐水作为安慰剂对照。
结果
实验组与安慰剂对照组在心率、呼吸频率、峰流速和一秒用力呼气容积方面存在显著差异。A2 组和 B1 组之间以及 A1 组和 B2 组之间无显著差异。
结论
吸入利多卡因对哮喘患者有益，特别是对激素抵抗性哮喘患者。
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