人工肝支持系统治疗急性中毒后肝功能衰竭。
Artificial liver support system in treatment of liver failure after acute poisoning.
机构信息
Department of Gastroenterology, Zhongshan Hospital Affiliated to Xiamen University, Xiamen 361004, China.
出版信息
World J Emerg Med. 2011;2(4):283-6. doi: 10.5847/wjem.j.1920-8642.2011.04.007.
BACKGROUND
Acute poisoning (AP) may cause failure of the liver and kidney, and even death. This study aimed to investigate the efficacy of artificial liver support system (ALSS) on the treatment of liver failure after acute poisoning.
METHODS
A total of 31 patients with liver failure caused by AP were admitted to emergency ICU, central ICU, and Department of Gastroenterology from 2005 to 2009 in Zhongshan Hospital Affiliated to Xiamen University, China. Among them, 13 patients served as a treatment group, and used ALSS in addition to detoxification treatment and protective treatment of liver function, and the other 18 patients served as a control group receiving detoxification treatment and protective treatment of liver function.
RESULTS
In the treatment group, 10 patients (76.9%) were cured or improved, 2 died, and 1 was discharged against advice. In the 18 patients in the control group, 7 (38.9%) were cured or improved, 3 died, and 8 were discharged against advice. There was a significant difference in the rates of improvement between the two groups (P<0.05).
CONCLUSION
ALSS is a safe and effective clinical method for the treatment of acute toxic liver failure.
背景
急性中毒（AP）可导致肝、肾功能衰竭，甚至死亡。本研究旨在探讨人工肝支持系统（ALSS）治疗急性中毒后肝衰竭的疗效。
方法
2005 年至 2009 年，我们对中国厦门中山医院急诊 ICU、中心 ICU 和消化内科收治的 31 例由 AP 引起的肝衰竭患者进行了研究。其中 13 例患者作为治疗组，除了进行解毒和保肝治疗外，还使用 ALSS；其余 18 例患者作为对照组，仅进行解毒和保肝治疗。
结果
治疗组 10 例（76.9%）治愈或好转，2 例死亡，1 例自动出院；对照组 18 例中，7 例（38.9%）治愈或好转，3 例死亡，8 例自动出院。两组患者的好转率差异有统计学意义（P<0.05）。
结论
ALSS 是治疗急性中毒性肝衰竭的一种安全有效的临床方法。
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