Wang Wen, Zhang Zhiheng, Yang Guiling, Wang Qiang
a Institute of Quality and Standard for Agro-products, Zhejiang Academy of Agricultural Sciences , Hangzhou , China.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014;31(11):1861-71. doi: 10.1080/19440049.2014.964336. Epub 2014 Oct 7.
A quantitative risk assessment was carried out to characterise the health risk from nickel (Ni) via dietary exposure for Chinese consumers. Ni contamination in foods was investigated by conducting a survey and a literature review. The daily diet of the public was categorised into nine food groups and the consumption data for each group were obtained from a nationwide survey. Deterministic and probabilistic methods were applied to calculate the target hazard quotients (THQs) by comparing the estimated dietary Ni intake with respect to the tolerable daily intake (TDI). The average estimated daily Ni intake (μg kg(-1) bw day(-1)) for men, women, 2-3-year-old children and 4-17-year-old children were 7.2, 7.3, 17.1 and 10.0, respectively. The consumption of cereals, beans, vegetables and marine products contributed significantly to the total daily intake of Ni. The mean THQ values (95% confidence interval) and the probability of dietary Ni exposure higher than the TDI were 0.60 (0.58-0.62) and 8.2% for men, 0.61 (0.59-0.63) and 8.4% for women, 1.35 (1.32-1.39) and 72.0% for 2-3-year-old children, and 0.87 (0.82-0.91) and 28.5% for 4-17-year-old children, respectively. This study showed a potential health risk from Ni via dietary exposure for Chinese consumers, especially among children.
开展了一项定量风险评估,以表征中国消费者通过饮食接触镍(Ni)所带来的健康风险。通过进行一项调查和文献综述,对食品中的镍污染情况进行了研究。公众的日常饮食被分为九个食物类别,并从一项全国性调查中获取了每个类别的消费数据。通过将估计的饮食镍摄入量与可耐受每日摄入量(TDI)进行比较,应用确定性和概率性方法来计算目标危害商数(THQ)。男性、女性、2至3岁儿童和4至17岁儿童的平均估计每日镍摄入量(μg kg⁻¹ bw day⁻¹)分别为7.2、7.3、17.1和10.0。谷物、豆类、蔬菜和海产品的消费对镍的每日总摄入量贡献显著。男性的平均THQ值(95%置信区间)以及饮食镍暴露高于TDI的概率分别为0.60(0.58 - 0.62)和8.2%,女性分别为0.61(0.59 - 0.63)和8.4%,2至3岁儿童分别为1.35(1.32 - 1.39)和72.0%,4至17岁儿童分别为0.87(0.82 - 0.91)和28.5%。这项研究表明,中国消费者通过饮食接触镍存在潜在健康风险,尤其是在儿童中。