代谢与其他脂肪：线粒体中的原钙黏蛋白。

Metabolism and the other fat: a protocadherin in mitochondria.

机构信息

Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Ophtalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY, USA.

Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.

出版信息

Cell. 2014 Sep 11;158(6):1240-1241. doi: 10.1016/j.cell.2014.08.039.

DOI:10.1016/j.cell.2014.08.039

PMID:25215484

Abstract

The protocadherin Fat is known as a tumor suppressor regulating growth in Drosophila and for its conserved function during planar cell polarity establishment. McNeill and colleagues now identify an unsuspected role for a C-terminal proteolytic product of Fat in mitochondria: regulating the electron transport machinery and metabolism.

摘要

原钙黏蛋白 Fat 作为一种肿瘤抑制因子，在果蝇中调节生长，并且在平面细胞极性建立过程中具有保守功能。现在，McNeill 及其同事发现了 Fat 的 C 端蛋白水解产物在线粒体中的一个意想不到的作用：调节电子传递机制和代谢。