抗癌药物与人工合成甜味剂的结合：糖精（Sac）和硫代糖精（Tsac）配合物顺式-[Pt(Sac)₂(NH₃)₂]和顺式-[Pt(Tsac)₂(NH₃)₂]的合成及抗癌活性
Combining anti-cancer drugs with artificial sweeteners: synthesis and anti-cancer activity of saccharinate (sac) and thiosaccharinate (tsac) complexes cis-[Pt(sac)2(NH3)2] and cis-[Pt(tsac)2(NH3)2].
作者信息
Al-Jibori Subhi A, Al-Jibori Ghassan H, Al-Hayaly Lamaan J, Wagner Christoph, Schmidt Harry, Timur Suna, Baris Barlas F, Subasi Elif, Ghosh Shishir, Hogarth Graeme
机构信息
Department of Chemistry, College of Science, University of Tikrit, Tikrit, Iraq.
Department of Chemistry, College of Science, University of Tikrit, Tikrit, Iraq.
出版信息
J Inorg Biochem. 2014 Dec;141:55-57. doi: 10.1016/j.jinorgbio.2014.07.017. Epub 2014 Aug 1.
The new platinum(II) complexes cis-[Pt(sac)2(NH3)2] (sac=saccharinate) and cis-[Pt(tsac)2(NH3)2] (tsac=thiosaccharinate) have been prepared, the X-ray crystal structure of cis-[Pt(sac)2(NH3)2] x H2O reveals that both saccharinate anions are N-bound in a cis-arrangement being inequivalent in both the solid-state and in solution at room temperature. Preliminary anti-cancer activity has been assessed against A549 human alveolar type-II like cell lines with the thiosaccharinate complex showing good activity.
已制备出新型铂（II）配合物顺式-[Pt（sac）₂（NH₃）₂]（sac = 糖精）和顺式-[Pt（tsac）₂（NH₃）₂]（tsac = 硫代糖精），顺式-[Pt（sac）₂（NH₃）₂]·H₂O的X射线晶体结构表明，两个糖精阴离子均以顺式排列通过氮原子结合，在室温下的固态和溶液中均不等价。已针对A549人II型肺泡样细胞系评估了初步抗癌活性，硫代糖精配合物显示出良好的活性。
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