Erb-Eigner Katharina, Bohner Georg, Goektas Oender, Harms Lutz, Holinski Franca, Schmidt Felix Alexander, Dahlslett Bettina, Dommes Esther, Asbach Patrick, Lüdemann Lutz
Department of Radiology, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany.
Department of Neuroradiology, Charité - Universitätsmedizin Berlin, Campus Mitte, 10117 Berlin, Germany.
J Neurol Sci. 2014 Nov 15;346(1-2):235-40. doi: 10.1016/j.jns.2014.08.039. Epub 2014 Aug 29.
To investigate diffusion tensor abnormalities, e.g. fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD), in olfactory structures of multiple sclerosis (MS) patients using diffusion tensor imaging (DTI).
Institutional review board-approved prospective study on 30 MS patients and 12 healthy controls investigated with MRI including DTI. Central olfactory structures were labelled on each patient's and healthy contro''s DTI volume. The diffusion tensor was determined in the central olfactory structures in MS patients. Tract-based spatial statistics (TBSS) was used to quantify the streamlines outgoing from the olfactory structures and to quantify changes in FA, MD, and RD within olfactory structures. These brain changes were correlated with olfactory function measured as TDI (Threshold, Discrimination, Identification) scores in patients and compared to our own reference group of 30 healthy volunteers.
Central olfactory structures in the MNI (Montreal Neurological Institute) data volume comprise 4808 voxels (4808 mm(3)). TFCE (Threshold-free cluster enhancement) and cluster analysis of patients identified a total of 127 voxels in one cluster with a significantly decreased FA (p<0.05) and none for MD and RD within olfactory structures compared to healthy controls. The correlation with the age-normalised Identification subscore of the TDI score increased the significant number of voxels with decreased FA to 208 voxels, with increased MD to 370 and with increased RD 364 voxels at the same region.
The decrease in FA and increase of MD and RD correlate with the degree of identification impairment of olfactory function in MS patients and clusters of abnormalities were identified on a MNI data volume.
使用扩散张量成像（DTI）研究多发性硬化症（MS）患者嗅觉结构中的扩散张量异常，例如分数各向异性（FA）、平均扩散率（MD）和径向扩散率（RD）。
经机构审查委员会批准，对30例MS患者和12名健康对照者进行了包括DTI在内的MRI前瞻性研究。在每位患者和健康对照者的DTI容积上标记中央嗅觉结构。测定MS患者中央嗅觉结构中的扩散张量。基于纤维束的空间统计学（TBSS）用于量化从嗅觉结构发出的纤维束，并量化嗅觉结构内FA、MD和RD的变化。这些脑部变化与患者以TDI（阈值、辨别力、识别力）评分衡量的嗅觉功能相关，并与我们自己的30名健康志愿者参考组进行比较。
MNI（蒙特利尔神经病学研究所）数据容积中的中央嗅觉结构包括4808个体素（4808立方毫米）。对患者进行的TFCE（无阈值聚类增强）和聚类分析在一个聚类中总共识别出127个体素，与健康对照相比，嗅觉结构内FA显著降低（p<0.05），MD和RD无显著变化。与TDI评分的年龄标准化识别子评分的相关性使同一区域FA降低的体素数量显著增加至208个，MD增加的体素数量至370个，RD增加的体素数量至364个。
MS患者中FA的降低以及MD和RD的增加与嗅觉功能识别损害程度相关，并且在MNI数据容积上识别出了异常聚类。
