脑区特异性白质退变与衰老：鹿特丹研究。
Tract-specific white matter degeneration in aging: the Rotterdam Study.
机构信息
Department of Radiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Medical informatics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Department of Radiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Neurology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
出版信息
Alzheimers Dement. 2015 Mar;11(3):321-30. doi: 10.1016/j.jalz.2014.06.011. Epub 2014 Sep 10.
BACKGROUND
Loss of brain white matter microstructure is presumed to be an early sign of neurodegenerative disease. Yet, little is known on microstructural changes of various white matter tracts with normal aging.
METHODS
In 4532 nondemented elderly persons, we studied age-related changes in tract-specific diffusion characteristics for 25 tracts using probabilistic tractography. We studied how diffusion differs across tracts with aging, whether this depends on macrostructural white matter changes, and whether cardiovascular risk factors affect microstructure.
RESULTS
With increasing age, loss of microstructural organization occurred in association, commissural and limbic tracts. White matter lesions and atrophy each partially explained this loss. We observed worse microstructure with severe hypertension, current smoking and diabetes mellitus, independent from age and macrostructural white matter changes.
CONCLUSIONS
Microstructure of white matter tracts changes with age, and may mark neurodegeneration more sensitively than white matter lesion load and atrophy. Cardiovascular factors relate to loss in microstructural organization.
背景
脑白质微观结构的丧失被认为是神经退行性疾病的早期迹象。然而，对于正常衰老过程中各种白质束的微观结构变化知之甚少。
方法
在 4532 名非痴呆老年人中，我们使用概率追踪法研究了 25 条束的束特异性扩散特征与年龄相关的变化。我们研究了扩散在不同束中随年龄的变化，这种变化是否取决于白质的宏观结构变化，以及心血管危险因素是否会影响微观结构。
结果
随着年龄的增长，与联合、连合和边缘束相关的微观结构组织丧失。白质病变和萎缩部分解释了这种丢失。我们观察到严重高血压、当前吸烟和糖尿病与年龄和白质宏观结构变化无关，与较差的微观结构有关。
结论
白质束的微观结构随年龄而变化，与白质病变负荷和萎缩相比，可能更敏感地标记神经退行性变。心血管因素与微观结构组织丧失有关。
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