精神分裂症风险基因MIR137、TCF4和ZNF804A对大脑宏观结构无影响。
No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure.
作者信息
Cousijn Helena, Eissing Marc, Fernández Guillén, Fisher Simon E, Franke Barbara, Zwiers Marcel, Harrison Paul J, Arias-Vásquez Alejandro
机构信息
Department of Psychiatry, University of Oxford, Oxford, UK.
Department of Psychiatry, University of Oxford, Oxford, UK; Donders Institute for Brain, Cognition and Behaviour, Departments of Psychiatry, Human Genetics & Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands.
出版信息
Schizophr Res. 2014 Nov;159(2-3):329-32. doi: 10.1016/j.schres.2014.08.007. Epub 2014 Sep 10.
Abstract
Single nucleotide polymorphisms (SNPs) within the MIR137, TCF4, and ZNF804A genes show genome-wide association to schizophrenia. However, the biological basis for the associations is unknown. Here, we tested the effects of these genes on brain structure in 1300 healthy adults. Using volumetry and voxel-based morphometry, neither gene-wide effects--including the combined effect of the genes--nor single SNP effects--including specific psychosis risk SNPs--were found on total brain volume, grey matter, white matter, or hippocampal volume. These results suggest that the associations between these risk genes and schizophrenia are unlikely to be mediated via effects on macroscopic brain structure.
摘要
MIR137、TCF4和ZNF804A基因内的单核苷酸多态性（SNP）显示出与精神分裂症的全基因组关联。然而，这些关联的生物学基础尚不清楚。在此，我们在1300名健康成年人中测试了这些基因对脑结构的影响。使用容积测量法和基于体素的形态测量法，未发现这些基因的全基因效应（包括这些基因的联合效应）或单个SNP效应（包括特定的精神病风险SNP）对全脑体积、灰质、白质或海马体体积有影响。这些结果表明，这些风险基因与精神分裂症之间的关联不太可能通过对宏观脑结构的影响来介导。
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