Toll样受体3跨膜结构域能够进行多种同型相互作用：一项核磁共振结构研究。
Toll-like receptor 3 transmembrane domain is able to perform various homotypic interactions: an NMR structural study.
作者信息
Mineev Konstantin S, Goncharuk Sergey A, Arseniev Alexander S
机构信息
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences RAS, Str. Miklukho-Maklaya 16/10, Moscow 117997, Russian Federation.
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences RAS, Str. Miklukho-Maklaya 16/10, Moscow 117997, Russian Federation; Lomonosov Moscow State University, Moscow 119991, Russian Federation.
出版信息
FEBS Lett. 2014 Nov 3;588(21):3802-7. doi: 10.1016/j.febslet.2014.08.031. Epub 2014 Sep 12.
Toll-like receptors (TLRs) take part in both the innate and adaptive immune systems. The role of the transmembrane domain in TLR signaling is still elusive, while its importance for the TLR activation was clearly demonstrated. In the present study the ability of the TLR3 transmembrane domain to form dimers and trimers in detergent micelles was shown by solution NMR spectroscopy. Spatial structures and free energy magnitudes were determined for the TLR3 transmembrane domain in dimeric and trimeric states, and two possible surfaces that may be used for the helix-helix interaction by the full-length TLR3 were revealed.
Toll样受体（TLRs）参与先天性和适应性免疫系统。跨膜结构域在TLR信号传导中的作用仍不清楚，但其对TLR激活的重要性已得到明确证实。在本研究中，通过溶液核磁共振光谱显示了TLR3跨膜结构域在去污剂胶束中形成二聚体和三聚体的能力。确定了二聚体和三聚体状态下TLR3跨膜结构域的空间结构和自由能大小，并揭示了全长TLR3可能用于螺旋-螺旋相互作用的两个表面。
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