Li Kainan, Zhong Chen, Wang Jun, Wang Baocheng, He Jun, Bi Jingwang
Department of Oncology, General Hospital of Jinan Military Region, No. 25 Shifan Road, Jinan, 250031, Shandong Province, People's Republic of China.
Tumour Biol. 2014 Dec;35(12):12519-23. doi: 10.1007/s13277-014-2570-0. Epub 2014 Sep 14.
Epidemiologic and biological data suggest a role for androgens and perhaps their receptor in hepatocellular carcinoma (HCC) development. However, few studies evaluated an association between HCC risk and androgen receptor (AR) cytosine, adenine, guanine (CAG) repeat length. To examine whether the relationship between the AR CAG repeats and HCC risk was also evident in Chinese, we conducted this large population-based, case-control study of 2,000 pathologically confirmed HCC patients and 2,000 frequency-matched controls. Two different approaches for AR CAG repeat length (analyses with continuous and categorized polymorphism variables) were conducted in the statistical analyses. For AR CAG longer allele (CAG_L), we found that subjects with longer AR CAG_L repeats had a decreased risk of developing HCC (OR = 0.87 for per CAG_A increase, 95 % CI 0.82-0.96, P = 5.33 × 10(-4)). Compared to those with the shorter (<23) CAG_L repeat length, subjects in the category of longer (≥23) CAG_L repeats had a significant 20 % decreased HCC risk (OR = 0.80, 95 % CI 0.71-0.91, P = 6.16 × 10(-4)). These findings suggest that androgen signaling underlies the development of HCC.
流行病学和生物学数据表明雄激素及其受体在肝细胞癌（HCC）发生过程中发挥作用。然而，很少有研究评估HCC风险与雄激素受体（AR）胞嘧啶、腺嘌呤、鸟嘌呤（CAG）重复长度之间的关联。为了研究AR CAG重复序列与HCC风险之间的关系在中国人群中是否也很明显，我们开展了这项基于人群的大型病例对照研究，纳入2000例经病理确诊的HCC患者和2000例频率匹配的对照。统计分析采用两种不同方法分析AR CAG重复长度（连续多态性变量分析和分类多态性变量分析）。对于AR CAG较长等位基因（CAG_L），我们发现AR CAG_L重复序列较长的受试者发生HCC的风险降低（每增加一个CAG_A，OR = 0.87，95%CI 0.82 - 0.96，P = 5.33×10⁻⁴）。与CAG_L重复长度较短（<23）的受试者相比，CAG_L重复长度较长（≥23）的受试者HCC风险显著降低20%（OR = 0.80，95%CI 0.71 - 0.91，P = 6.16×10⁻⁴）。这些发现表明雄激素信号传导是HCC发生的基础。
