雄激素受体CAG重复多态性与上皮性卵巢癌风险的关联。

Association of androgen receptor CAG repeat polymorphism and risk of epithelial ovarian cancer.

作者信息

Zhu Tongyu, Yuan Jing, Xie Yudou, Li Hong, Wang Yuzhi

机构信息

Dept. of Obstetrics and Gynecology, General Hospital of Jinan Military Command, Jinan, Shandong Province 250031, People's Republic of China.

Dept. of Medical Information, General Hospital of Jinan Military Command, Jinan, Shandong Province 250031, People's Republic of China.

出版信息

Gene. 2016 Jan 10;575(2 Pt 3):743-6. doi: 10.1016/j.gene.2015.09.054. Epub 2015 Sep 26.

DOI:10.1016/j.gene.2015.09.054

PMID:26410037

Abstract

BACKGROUND

Biological and epidemiologic evidence suggested that androgen and its receptor may play an important role in ovarian carcinogenesis. However, results of previous association studies about ovarian cancer and AR CAG repeat polymorphism were inconsistent. Furthermore, none of these studies were conducted in Asians.

METHODS

We evaluated the relationship between AR CAG repeat length and epithelial ovarian cancer (EOC) risk among a Chinese population including 1800 pathologically confirmed EOC patients and 1800 frequency matched controls.

RESULTS

Women with longer AR CAG repeats had a decreased EOC risk (OR=0.87 for per CAG_A increase, 95% CI: 0.81-0.95). Compared to those with shorter (<22) CAG_A repeat length, women with of longer (≥22) CAG_A repeats had a 34% decreased EOC risk (OR=0.66, 95% CI: 0.57-0.75). For CAG_S and CAG_L, the results remained consistent.

CONCLUSIONS

Our findings suggest that androgen signaling contributes to the development of ovarian cancer.

摘要

背景

生物学和流行病学证据表明，雄激素及其受体可能在卵巢癌发生过程中发挥重要作用。然而，先前关于卵巢癌与雄激素受体（AR）CAG重复多态性的关联研究结果并不一致。此外，这些研究均未在亚洲人群中开展。

方法

我们评估了中国人群中AR CAG重复长度与上皮性卵巢癌（EOC）风险之间的关系，该人群包括1800例经病理确诊的EOC患者和1800例频率匹配的对照。

结果

AR CAG重复序列较长的女性患EOC的风险降低（每增加一个CAG_A，OR = 0.87，95% CI：0.81 - 0.95）。与CAG_A重复长度较短（<22）的女性相比，CAG_A重复长度较长（≥22）的女性患EOC的风险降低34%（OR = 0.66，95% CI：0.57 - 0.75）。对于CAG_S和CAG_L，结果保持一致。