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利伐沙班引起的严重弥漫性脑出血。

Rıvaroxaban-induced severe diffuse ıntracerebral hemorrhage.

作者信息

Çalışkan Fatih, Akdemir Hızır Ufuk, Nurata Hakan, Akdemir Neslihan, Başara Gökhan, Yavuz Yücel

机构信息

Department of Emergency Medicine, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.

Department of Emergency Medicine, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.

出版信息

Am J Emerg Med. 2015 Mar;33(3):475.e1-5. doi: 10.1016/j.ajem.2014.08.028. Epub 2014 Aug 21.

DOI:10.1016/j.ajem.2014.08.028
PMID:25218622
Abstract

Bleeding, the most frightening adverse effect of anticoagulants,may occur in different parts of the body.When intracerebral hemorrhage in individuals used anticoagulant drugs is compared with normal coagulation function, the volume of bleeding is increased and the prognosis is worse. There are few studies in the literature regarding the presence of intracerebral hemorrhage and the volume and prognosis of bleeding associated with rivaroxaban, a new oral anticoagulant.Therefore, the clinical and radiologic findings and follow-up of an 80-year-old male patient with intracerebral hemorrhage who uses rivaroxaban for anticoagulation are presented in this article.

摘要

出血是抗凝剂最可怕的不良反应,可能发生在身体的不同部位。与凝血功能正常的个体相比,使用抗凝药物的个体发生脑出血时,出血量会增加且预后更差。关于新型口服抗凝剂利伐沙班相关的脑出血情况、出血量及预后,文献中的研究较少。因此,本文介绍了一名使用利伐沙班进行抗凝治疗的80岁男性脑出血患者的临床和影像学表现及随访情况。

相似文献

1
Rıvaroxaban-induced severe diffuse ıntracerebral hemorrhage.利伐沙班引起的严重弥漫性脑出血。
Am J Emerg Med. 2015 Mar;33(3):475.e1-5. doi: 10.1016/j.ajem.2014.08.028. Epub 2014 Aug 21.
2
Life-threatening haemorrhagic pericarditis associated with rivaroxaban.与利伐沙班相关的危及生命的出血性心包炎。
Int J Cardiol. 2014 Jun 15;174(2):e75-6. doi: 10.1016/j.ijcard.2014.04.151. Epub 2014 Apr 21.
3
Cerebral hemorrhage under rivaroxaban.
Int J Cardiol. 2013 Sep 10;167(6):e179-81. doi: 10.1016/j.ijcard.2013.03.185. Epub 2013 May 4.
4
Management of major bleeding events in patients treated with rivaroxaban vs. warfarin: results from the ROCKET AF trial.利伐沙班与华法林治疗患者大出血事件的管理:来自 ROCKET AF 试验的结果。
Eur Heart J. 2014 Jul 21;35(28):1873-80. doi: 10.1093/eurheartj/ehu083. Epub 2014 Mar 21.
5
Cardiac Tamponade Associated with Rivaroxaban.与利伐沙班相关的心包填塞
Del Med J. 2015 Jul;87(7):206-7.
6
Rivaroxaban 2.5 mg. No justification for using this anticoagulant after an acute coronary syndrome.利伐沙班2.5毫克。急性冠状动脉综合征后使用这种抗凝剂没有依据。
Prescrire Int. 2014 Oct;23(153):229-32.
7
Rivaroxaban in acute coronary syndromes--is it prime time?利伐沙班用于急性冠状动脉综合征——时机已到?
Expert Rev Cardiovasc Ther. 2014 Jun;12(6):649-58. doi: 10.1586/14779072.2014.910118. Epub 2014 Apr 19.
8
Isolated hemopericardium associated with rivaroxaban: first case report.与利伐沙班相关的孤立性心包积血:首例病例报告。
Pharmacotherapy. 2014 Sep;34(9):e169-72. doi: 10.1002/phar.1474. Epub 2014 Jul 30.
9
Favorable outcome of rivaroxaban-associated intracerebral hemorrhage reversed by 4-factor prothrombin complex concentrate: impact on thrombin generation.4 因子凝血酶原复合物浓缩剂逆转利伐沙班相关脑出血的良好结局:对凝血酶生成的影响
A A Case Rep. 2015 Jun 1;4(11):151-4. doi: 10.1213/XAA.0000000000000143.
10
[Comparison of the safety of rivaroxaban versus dabigatran therapy in patients with persistent atrial fibrillation].利伐沙班与达比加群治疗持续性心房颤动患者的安全性比较
Pol Merkur Lekarski. 2014 Nov;37(221):261-4.

引用本文的文献

1
Preventability of serious thromboembolic and bleeding events related to the use of oral anticoagulants: a prospective study.口服抗凝剂相关严重血栓栓塞和出血事件的可预防性:一项前瞻性研究。
Br J Clin Pharmacol. 2018 Jul;84(7):1544-1556. doi: 10.1111/bcp.13580. Epub 2018 Apr 17.
2
Safety profile of the direct oral anticoagulants: an analysis of the WHO database of adverse drug reactions.直接口服抗凝剂的安全性概况:对世界卫生组织药品不良反应数据库的分析
Br J Clin Pharmacol. 2017 Jul;83(7):1532-1543. doi: 10.1111/bcp.13234. Epub 2017 Mar 19.