Yale Center for Molecular Discovery, West Haven, CT 06516, USA.
Yale Center for Molecular Discovery, West Haven, CT 06516, USA.
Drug Discov Today. 2016 Jan;21(1):1-4. doi: 10.1016/j.drudis.2014.09.001. Epub 2014 Sep 15.
Following the introduction of antibiotic therapy and widespread inoculations, cardiovascular diseases have leapt ahead of infectious diseases in terms of prevalence in much of the developed and developing world. Herein, we assess FDA-approved drugs for the treatment of cardiovascular diseases. The drug development enterprise around cardiovascular diseases has remained stable in contrast to turbulent changes in other therapeutic indications. However, upon closer inspection, the results identify narrow scope in terms of the breadth of targets and the mechanistic actions of new drugs. From the public health point of view, it is important to balance incremental change with orthogonal innovations that are needed to combat a leading cause of morbidity and mortality.
在抗生素治疗和广泛接种疫苗的引入之后，心血管疾病在发达国家和发展中国家的大部分地区的患病率已经超过了传染病。在此，我们评估了 FDA 批准用于治疗心血管疾病的药物。与其他治疗领域的动荡变化相比，心血管疾病药物的研发企业一直保持稳定。然而，仔细观察结果表明，新药的靶点广度和作用机制方面仍然存在局限性。从公共卫生的角度来看，重要的是要平衡渐进式变化与需要对抗发病率和死亡率主要原因的正交创新。
