舒必利治疗急性躁狂症，并比较锂盐和舒必利治疗对血浆激素浓度的影响。

Sulpiride treatment of acute mania with a comparison of the effects on plasma hormone concentrations of lithium and sulpiride treatment.

作者信息

Christie J E, Whalley L J, Hunter R, Bennie J, Fink G

机构信息

MRC Brain Metabolism Unit, Royal Edinburgh Hospital, U.K.

出版信息

J Affect Disord. 1989 Mar-Jun;16(2-3):115-20. doi: 10.1016/0165-0327(89)90064-5.

DOI:10.1016/0165-0327(89)90064-5

PMID:2522110

Abstract

Sulpiride, in this open study of acute manic patients, had a clear antimanic action with all eight patients responding to sulpiride treatment without the need for other antipsychotic drugs. Plasma prolactin concentrations were increased and oestrogen-stimulated neurophysin concentrations decreased by sulpiride but were unchanged by lithium treatment, whereas TSH concentrations showed a rapid increase following the introduction of lithium therapy.

摘要

在这项针对急性躁狂症患者的开放性研究中，舒必利对所有八名患者均有明显的抗躁狂作用，这些患者对舒必利治疗有反应，无需使用其他抗精神病药物。舒必利可使血浆催乳素浓度升高，雌激素刺激的神经垂体素浓度降低，而锂治疗对此无影响，而在开始锂治疗后促甲状腺激素浓度迅速升高。